With the collaboration of
Con la colaboración de

Program

15.00 – 17:05 h

First Session

Moderators: Alberto Bartolomé (CIBERDEM) and Marta Fortuny (CIBEREHD)

15:00 – 15:25 h

Dr. Edilmar Alvarado: “Strategies for preventing cirrhosis decompensation: the role of glucose-lowering drugs.” ONLINE

15:25 – 15:50 h

Dr. Carla Borràs Querol: “PCSK9 inhibitors shift macrophage cholesterol efflux distribution in Familial Hypercholesterolemia”

15:50 – 16:15 h

Dr. Diego Ceacero: “Pharmacological, immunological and nutritional modulation of intestinal barrier function.”

16:15 – 16:40 h

Dr. Mariana Gomes: “Clinical and molecular spectrum of syndromic diabetes in a large Spanish cohort using a targeted NGS panel”

16:40 – 17:05 h

Dr. Isabella Dotti: “Uncovering epithelial barrier dysfunction and therapeutic opportunities in IBD with organoid-derived intestinal models”

17:05 – 17:35 h

Coffee Break

17:35 - 18:50 h

Second Session

Moderators: Victòria Ceperuelo Mallafré (CIBERDEM) and Fabio Suárez (CIBEREHD)

17:35 – 18:00 h

Dr. Sílvia Bonàs Guarch: “The polygenic architecture of the insulin secretory function provides biological insights into type 2 diabetes aetiology.”

18:00 – 18:25 h

Dr. María Ester González Sánchez: “The role of the EGFR signaling pathway in chronic liver disease.”

18:25 – 18:50 h

Dr. Carlos Castaño: “Isolation and Characterization of Circulating Bacterial Extracellular Vesicles: A Novel Approach to Understanding Host- Microbiome Interactions in Obesity.”

18:50 – 19:50 h

Keynote speaker:

Dr. Cintia Folgueira Cobos: "Uncovering new pathways in metabolic communication and body weight regulation"

19:50 – 20:00 h

Closing Remarks

09:00-09:30 h

Welcome Session

Presentation of CIBERDEM, Dr. Didac Mauricio, Scientific Director of CIBERDEM

Presentation of CIBEREHD, Dr. Jordi Gracia, Scientific Director of CIBEREHD

09:30 - 11:00 h

Joint Session: “What Can CIBEREHD Offer CIBERDEM, and Vice Versa?”

Moderators:Dr. Sonia Fernández-Veledo (CIBERDEM), Dr. María Chaparro (CIBEREHD)

09:30 - 10:15 h

CIBERDEM Contributions:

  • Dr. Alex Mesa: “MASLD in Type 1 Diabetes”
  • Dr. Ángela Martínez-Valverde: “Inter-organ Crosstalk in the Treatment of Metabolic Diseases”

10:15 - 11:00 h

CIBEREHD Contributions:

  • Dr. Javier Santos: “Neuroendocrine Regulation and Nutrition in Functional and Inflammatory Digestive Diseases: New Therapeutic Perspectives”
  • Dr. Ángel Lanas: “Regenerative Medicine and Genetic-Environmental Determinants in Inflammatory and Tumoral Digestive Tract Diseases”

11:00 – 11:30 h

Coffee Break and Networking

11:30 - 12:15 h

CIBEREHD Plenary Session

Moderator: Dr. Juan Manuel Pericás (CIBEREHD)

Dr. Chantal Desdouets “Key insights on Immunometabolism to define future therapeutic strategies on metabolic-dysfunction associated liver disease”

12:15 - 13:00 h

CIBERDEM Plenary Session:

Moderators: Dr. Ángela Martínez Valverde

Dr. Francesco Giorgino: “Incretin-based Therapies and Treatment of Obesity-related Diseases"

13:00 – 14:15 h

Lunch

14:15 – 14:30 h

CIBER Scientific Culture Unit

14:30 - 15:30 h

Scientific research support units

Moderators: Dr. Manel Vázquez (CIBERDEM) and Dr. María Arechederra (CIBEREHD)

  • Metabolomic Unit: Dr. Óscar Yanes / Dr. Maria Vinaixa
  • CIC Biogune – CIBEREHD: Dr. Juan Manuel Falcón
  • Bioinformatic Platform– CIBEREHD: Dra. Yulia Sidorova
  • Diabetes and Metabolic Diseases Biorepository CIBERDEM-IDIBAPS: Dr. Laura Brugnara

15:30 - 17:00 h

Collaborative projects between CIBERDEM and CIBEREHD

Moderators: Dr. Marc Liesa (CIBERDEM) and Dr. María Reig (CIBEREHD)

Ongoing Projects:

  • UNMASK Project Leads: Jordi Gracia, Rocío Gallego, Javier Cubero, Rubén Francés + Fran Martín
  • Portal Hypertension and New Metabolic Mechanisms in MASLD Progression: SHBG and Intestinal Receptors as Emerging TargetsLead: Juanma Pericas
Presentations of Collaborative CIBERDEM–CIBEREHD Projects Selected from Submitted Abstracts

  • Dr. Marta Casado: “Protective role of COX-2 expression in hepatocytes during obstructive cholestasis and intrahepatic cholestasis of pregnancy: Implications for inflammation, bile acid metabolism, liver injury, and modulation of canalicular transporters”
  • Dr. Victòria Ceperuelo: “SUCNR1 as a metabolic and prognostic regulator in MASLD-Associated hepatocellular carcinoma”
  • Dr. Douglas Maya: “Cholestatic MASLD Exhibits Distinct Steroid, Lipid and Bile Acid Profiles: A Multicenter Metabolomics Study”
  • Dr. María Poca: “Impact of a multidisciplinary approach on liver and metabolic health outcomes in patients with fibrotic metabolic dysfunction-associated steatohepatitis: A single centre European experience”

17:00 - 18:30 h

Flash Talks and Poster Session

Moderators: Dr. Águeda González (CIBERDEM) and Dr. Naroa Goikoetxea (CIBEREHD)

Flash Talks

18:00 - 20:00 h

CIBERDEM Principal Investigators Meeting*

*Restricted to CIBERDEM PIs and co-PIs

SALA TRIANA

18:00 - 20:00 h

CIBERDEHD Principal Investigators Meeting*

*Restricted to CIBEREHD PIs and co-Pis

SALA DESCUBRIMIENTO

09:00-09:45 h

Inaugural session:

Moderator: Dr. Anabel Rojas

Dr. Jonatan Ruiz: “Impact of Intermittent Fasting and Exercise on Ectopic Fat Clearance and Cardiometabolic Risk”

09:45 - 10:45 h

Short Talks

Moderators: Dr. María Ángeles Balboa and Dr. Reinaldo Sousa

09:45 - 10:00 h

“Long non-coding RNAs a as a novel source of beta cell autoantigens in type 1 diabetes.”

Dr. Izortze Santin Gomez

10:00 - 10:15 h

“Mitochondrial fission promotes loss of beta cell identity.”

Kevin Andrés Rivera Loor

10:15 - 10:30 h

“Breaking molecular barriers to enhance the endocrine features of human fibroblasts-derived insulin producing cells.”

Marta Perea Atiénzar

10:30 - 10:45 h

“Age and sex modulation of the insulin resistance-TG-HDLc axis.”

Dr. Montse Guardiola Guionnet

10:45 - 11:15 h

Coffee Break

11:15 - 11:35 h

Flash Talks

Moderator: Dr. Nuria Valdés

11:15 - 11:18 h

“Beneficial effects of colonic metabolite supplementation in a preclinical model of type 2 diabetes.”

Paula Isabel Gallardo Villanueva

11:18 - 11:21 h

“HMG20A Protects β-Cells from Senescence and Functional Decline”

Dr. Petra I. Lorenzo

11:21 - 11:24 h

“TMEM164: Deciphering its Role in Lipid and Immunometabolism Regulation.”

Cristina Fraile Sánchez

11:24 - 11:27 h

“Lipidomic and glycoprotein signatures in women with polycystic ovary syndrome: a comparative and longitudinal study.”

Dr. María Insenser

11:27 - 11:30 h

“Alx3 Deficiency Disrupts FFAR1 Signalling and impairs Glucose-Stimulated Insulin Secretion.”

Dr. Mercedes Mirasierra

11:30 - 12:15 h

Short Talks

Moderators: Dr. Rosa Gasa and Dr. Iván Quesada

11:30 - 12:15 h

“Decoding Gestational Diabetes Mellitus: The Role of TGF-β Signaling in pancreatic β-Cell Dysfunction and Glucose Intolerance.”

Dr. Paloma Alonso-Magdalena

11:45 - 12:00 h

“Extracellular vesicles as mediators of beta cell adaptation during obesity progression.”

Helena Marí de Nova

12:00 - 12:15 h

“Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue.”

Dr. Manuela Sánchez Feutrie

12:15 - 12:45 h

Patient engagement session

Moderator: Dr. Dídac Mauricio

Participants:

  • Ms. María José Salmerón Mínguez, Member of the Board of Directors of the Spanish Diabetes Federation (FEDE)
  • Dr. Francesc Mitjans, Scientific Director of DiabetesCero

12:45 - 13:15 h

Investigación traslacional: Cómo desarrollar un proyecto de película

Luzma García Piqueres, RTTP, Responsable de la Oficina de Transferencia del Conocimiento.

Dr. Juan Luque Moreno, Responsable de la Plataforma de Desarrollo Tecnológico.

13:15 - 13:30 h

Awards

09:00-09:30 h

CIBEREHD Results 2024

Dr. Jordi Gracia. Summary of Key Indicators, Scientific Advances, and Consortium Activities in the Past Year.

09:30 - 10:00 h

CIBEREHD Scientific Strategic Plan

Dr. Agustín Albillos. Presentation of the New Strategic Plan, Scientific Priorities, and Action Lines for the Coming Period.

10:00 - 11:00 h

Current Status of Intramural and Collaborative Projects

Moderator: Dr. Rafael Bañares

“A PREDictive signature in rectal cancer, treated with total neoadjuvant therapy, to increase the accuracy of WATCH and WAIT strategy.”

Dr. Joan Maurel

“Unraveling The impAct of time Restricted eating on the Gut-livEr connecTion in men and women with Obesity TARGET-O.”

Dr. Julio Galvez

"DELTHA Proof-of-concept study for in vivo delivering LSECtin-mRNA loaded lipid nanoparticles to hepatic antigen presenting cells."

Dr. Rubén Frances

"eoSPS Clinical, endoscopic, and molecular characterization of early-onset serrated polyposis syndrome"

Dra. Sabela Carballal

“Characterization of the Prognostic and Therapeutic Value of Hepatic Stellate Cell Subpopulations in Hepatic Fibrosis and Its Complications (CHEF)"

Dr. Antonio Gil

10:45 - 11:00 h

Dr. Jaume Bosch Genover (1947–2025)

Dr. Juan Carlos García Pagán “Maestro, pionero y alma fundadora del CIBER”

11:00 - 11:30 h

Coffee Break and networking

11:30 - 12:00 h

Status of Personnel Calls

Moderator: Dr. Rubén Francés.

  • Sra. Laura Fábrega Fernández. Ayuda predoctoral Jaume Bosch (2022). [1st Jaume Bosch Predoctoral Fellowship]
  • Sr. Antonio Segovia Zafra. Ayuda predoctoral Jaume Bosch (2022) [2nd Jaume Bosch Predoctoral Fellowship]
  • Dra. Maelle Locatelli. ARISTOS (1st Call 2024)
  • Dra. Malena Manzi. ARISTOS (1st Call 2024)

12:00 - 13:00 h

Hidden Collaborations

Moderator: Dr. José Juan García Marín.

Metabolic aging clocks for MASLD stratification.

Dr. Oscar Millet.

“Reproducción de la homeostasis y de los estímulos metabólicos durante la perfusión normotérmica prolongada en el hígado aislado”. [Reproducing Homeostasis and Metabolic Stimuli during Extended Normothermic Perfusion in Isolated Human Liver]

Dr. Constantino Fondevila.

“Del daño a la reparación: Interactomas y nuevas dianas en la fisiopatología de la Enfermedad Hepática Crónica”. [From Damage to Repair: Interactomes and New Targets in the Pathophysiology of Chronic Liver Disease]

Dra. Blanca Herrera.

“Immune4All: Exploring the Feasibility of predictive and pharmacodynamics biomarkers of immunotherapy in solid tumors”.

Dra. María Reig.

“Contribución diferencial del exposoma intestinal a la fisiopatología de la diarrea crónica en el síndrome del intestino irritable con y sin diarrea por ácidos biliares asociada. Perfil clínico-biológico para el diagnóstico diferencial”. [Differential Contribution of the Intestinal Exposome to the Pathophysiology of Chronic Diarrhea in IBS With and Without Bile Acid Diarrhea: Toward a Clinical–Biological Diagnostic Profile]

Dr. Javier Santos.

“Validación de biomarcadores multiómicos predictores de respuesta terapéutica en pacientes con enfermedad inflamatoria intestinal: un paso hacia la medicina personalizada”. [Validation of Multi-Omics Biomarkers Predictive of Therapeutic Response in Patients with Inflammatory Bowel Disease: A Step Toward Personalized Medicine]

Dra. Montserrat Baldán

“Caracterización del viroma hepático en pacientes con infección crónica por el virus de la hepatitis B (VHB) y D (HDV)” [Characterization of the Hepatic Virome in Patients with Chronic HBV and HDV Infection]

Dr. Josep Quer.

“Biomarcadores de imagen por RM en la respuesta al tratamiento edico en enfermedad perianal fistulizante”. [MRI Imaging Biomarkers of Response to Medical Treatment in Perianal Fistulizing Disease]

Dr. Jordi Rimola.

13:00 - 13:30 h

Citizen Engagement in CIBEREHD – Let’s Improve!

Moderator: Dra. Maria Arechederra

Presentation of the CIBER Citizen Engagement Action Plan 2025–2026: Where We Stand in EHD and Future Actions

Experiences from

Dr. Antoni Castells’ Group. Dra. Meritxell Gironella, Marta Blanco Álvarez (FAEECC)

Dr. Luís Bujanda’s Group. Dra. Laura Izquierdo Sánchez, Elisabeth Baucells (ATUBIVI)

13:30 - 13:45 h

Awards and Closing Session

Dr. Jodi Gracia. Award Ceremony, Roadmap to Upcoming Milestones, and Closing Remarks

13:45 - 14:30 h

Finger Lunch